Uwe Ohler studied computer science with a minor in biology at the University of Erlangen-Nuremberg. During a student research project involving computational DNA sequence analysis, he became fascinated with computational biology and started his PhD research at the Chair for Pattern Recognition. He was a Boehringer Ingelheim pre-doctoral fellow and a visiting researcher with the Berkeley Drosophila Genome Project. Ohler obtained his PhD with distinction in 2002 for the McPromoter system for computational identification of promoters in eukaryotic genomes. Before returning to Germany, Uwe lived in the US for more than a decade and followed his interests in gene regulation and applied machine learning. In 2005, he joined the faculty of the Institute of Genome Sciences & Policy at Duke University, Durham NC, USA, where he received tenure in 2011. He taught in the cross-departmental graduate program in Computational Biology & Bioinformatics, and was core faculty of the Duke Center for Systems Biology. During this time, Uwe received fellowships from the Alfred P Sloan Foundation, as well as HFSP, NSF CAREER, and NIH Transformative Research awards.